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Alzheimer's Prevention

GHR Foundation is partnering boldly with a consortium of government, industry, academic research and other philanthropists on a game-changing undertaking – the prevention of Alzheimer’s dementia.
By 2025, GHR Foundation aims to help develop a therapy to prevent Alzheimer’s dementia.  
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​We have committed more than $17 million over five years to scale up important research already underway. The Foundation is targeting funding to improve some of the largest research efforts in the field, including:

  • The Mayo Clinic Study of Aging: Research working to define the impact of Alzheimer's on the population and develop a screening approach to identify those at risk
  • Washington University's DIAN-TU Study: A study quickly evaluating potential prevention treatments among those who are most likely to develop the disease
  • The A4 Study: Research led by Dr. Reisa Sperling of Harvard University to determine the effectiveness of prevention therapy before Alzheimer's disease impacts the brain; this study is working toward FDA approval for prevention therapy in the general population
  • Banner Alzheimer’s Institute's APOE4 Trial: A study focused on determining whether therapies targeting amyloid proteins in the brain may prevent or delay Alzheimer’s symptoms in people with genetic risk for developing the disease at older ages

​While all research is uncertain, the potential to turn the tide and provide hope for all families that face Alzheimer’s has never been more promising.  
GHR Foundation Alzheimer's Onesheet

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GHR believes significant recent advances in Alzheimer’s research have created the scientific possibility of preventing Alzheimer’s dementia. 
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▪ Advances in brain imaging have made it possible to measure the development of Alzheimer plaques and tangles in the living brain

▪ Long-term studies have shown the plaques and tangles of Alzheimer’s dementia build-up 10-20 years prior to symptom onset

▪ Advances in genetics can now identify patients at greater risk even before they develop pathology
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▪ New experimental therapies offer the potential to intervene in the disease in a meaningful way for the first time

Alzheimer’s remains the sixth leading cause of death in the United States and has the highest cost impact on our economy.
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More than 5 million Americans are living with Alzheimer’s Disease.
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Alzheimer's Disease is the most expensive condition in the nation. Nearly one in every five dollars spent by Medicare is on people with Alzheimer's or another form of dementia.
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In 2020, family and friends provided 18.5 billion hours of unpaid care to those with Alzheimer's and other dementias – care valued at $234 billion.
Source: http://www.alz.org/facts/overview.asp
Alzheimer’s Association's 2020 Factsheet

Alzheimer's: Facts, Figures and Prevention 

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